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Toronto women fall ill more frequently in autoimmune diseases haiku seafood buffet because they have other bacteria in the gut than men? This conclusion can be experimental animal experiments in science;: to (2013 doi 10.1126 / science.1233521). They also show a berraschenden influence of intestinal flora on sex hormones.
The display team Jayne Danska from the Hospital for Sick Children in Toronto experimented with so-called non-obese diabetic or NOD muses. These animals have a strong genetic predisposition to a type 1 diabetes. Female animals were infected more often than much mnnliche animals.
This Geschlechtsspezifitt however did not exist when the animals raised in germ-free Kfigen. Then mnnliche and females are affected equally haiku seafood buffet frequently. The same effect had a transmission of enteric bacteria from adult mnnlichen on immature females: instead of 85 percent, only 25 percent of female NOD Muse have type 1 diabetes diseased.
The Fkal transplants had yet another unexpected result: In the female pups, there was an increase of mnnlichen sex hormone testosterone. Danska is convinced that this Vernderungen for the protective effect of Fkal transplants are responsible. If the Aktivitt haiku seafood buffet of testosterone haiku seafood buffet blocked, the protective effect was lost. The females were then more susceptible to a type 1 diabetes.
Why the exchange of intestinal flora in the female animals leads to an increase in testosterone levels is unclear. The researchers haiku seafood buffet can not explain haiku seafood buffet why the hormone reduced the Anflligkeit to autoimmune disease. Danska interprets the effects as a further facet of the hygiene hypothesis, the interaction haiku seafood buffet of bacteria on the immune system and influences haiku seafood buffet the development of autoimmune diseases. haiku seafood buffet
In order to avoid diseases, the immune system needs to be exposed to germs early stage of the environment. This apprenticeship of the immune system knnte take place mainly in the intestine. The gut-associated lymphoid tissue GALT (gut-associated lymphoid tissue) is anteilsmig the largest part of the human immune system.
Whether the results are transferable to humans, haiku seafood buffet is of course unclear. If an intestinal dysbiosis in humans the Anflligkeit erhhen on autoimmune diseases, knnte regulation of intestinal flora mglicherweise haiku seafood buffet have a protective effect. R0E / aerzteblatt.de Print Share Share
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